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Contrave is a combination with the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs which can be made up of more than one active ingredient, which may make them more potent and safer. Combo-pilling could be the newest fad or even better the newest ahead under scrutiny and thus it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that utilizing a combination of pills has become popular may be the fact that at the time of right now there aren't long term prescription weight loss supplements that have been approved by the FDA apart from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations happen to be rejected or have yet to be approved by the FDA. Seizures are a side effect with Contrave and really should not be taken in those with seizure disorders. 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